ASSOCIATION OF THE c.629C>T GENE POLYMORPHISM OF ANGIOTENSINOGEN GENE WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORNS

Abstract

The genotype distribution of the AGT c.629C>T (rs2067853) polymorphic variant was analyzed in newborns born at different gestational ages and their possible association with early neonatal outcomes was assessed. A total of 46 newborns with hypoxic-ischemic encephalopathy of different gestational ages were examined, with an average age of 34.2±4.03 weeks. The majority of newborns (58.7%) were premature (23-36 weeks), with the majority being late preterm (34-36 weeks) – 21.7%, and very preterm (28-31 weeks) – 17.5%. Extremely preterm (< 28 weeks) infants were less common – 6.5%. Fullterm infants (37-39 weeks) accounted for 41.3%. A predominance of the homozygous variant of the CC mutation was identified, which was observed with a considerably higher frequency among preterm infants. The presence of this variant may be associated with an increase in adverse outcomes, including death, which is related to impaired vascular adaptation and hemodynamic stability in infants of lower gestational age. The obtained results confirm the possible involvement of the AGT c.629C>T polymorphism in the mechanisms regulating vascular tone and adaptation during the neonatal period.