THE ROLE OF IRON METABOLISM PROTEINS IN THE PATHOGENESIS OF CHRONIC KIDNEY DISEASE

Abstract

The article presents the results of a study conducted to investigate the role of iron metabolism proteins in the pathogenesis of chronic kidney disease (CKD). The study included patients with stage II-III chronic kidney disease (CKD) who were not receiving hemodialysis (conservative group) and patients with end-stage CKD undergoing regular hemodialysis (terminal group). The study revealed that patients in the terminal group exhibited more severe anemia and iron deficiency. It was determined that, compared to the conservative group, the concentrations of ferritin, lactoferrin, ferroportin, and hepcidin were significantly elevated in the terminal group. The increase in the concentration of these proteins with disease progression proves their role in the pathogenesis of CKD and the formation of inflammatory processes.