LOCAL IMMUNOPROTECTIVE MECHANISMS OF MICROCIRCULATION IN BLEEDING GASTRODUODENAL ULCERS
DOI:
https://doi.org/10.34921/amj.2024.1.004Keywords:
Helicobacter Pylori, microcirculatory network, CD25, periulcer area, gastroduodenal ulcerAbstract
Clinical research was conducted on 173 patients diagnosed with gastroduodenal ulcer. Patients were divided into 2 groups accordingly. Group I (comparison group) consisted of 42 patients with gastric and duodenal ulcers not complicated by bleeding, group II (main) – 131 patients with gastric and duodenal ulcers complicated by acute bleeding, and a control group of 36 volunteers without somatic pathology.
The study results showed that the intensity of formation of abnormal thrombo-leukocyte aggregates (TLA) in the peripheral blood in patients with "gastroduodenal ulcer complicated by bleeding" increases sharply, causing deterioration of the rheological-thrombogenetic properties of bleeding-peripheral blood.
In patients with "gastroduodenal ulcer complicated by bleeding", the severe, irreversible changes of the microcirculation network of the ulcer bottom, peri-ulcerative and relative-remote areas are directly proportional to "active gastroduodenal bleeding of ulcer origin".
Bleeding complication of gastroduodenal ulcer is directly (directly proportional) with the increase in the density of CD25-positive cells in the gastroduodenal mucosa and submucosa. At the same time, the increase level of CD25-positive cells around small vessels correlates proportionally with the bleeding factor.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Azerbaijan Medical Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.