THE ROLE OF PREMORBID DISEASES IN THE DEVELOPMENT OF POLYARTERITIS NODOSA ASSOCIATED ACUTE HEPATITIS B

Abstract

The article presents the results of a study investigating the role of premorbid diseases in the development of polyarteritis nodosa in patients with acute hepatitis B. The main group consisted of 158 patients with acute hepatitis B: 61 of them complicated with polyarteritis nodosa and 97 without complications. The "American College of Rheumatologists" classification criteria proposed in 1990 were used to diagnose polyarteritis nodosa. During the observations in patients premorbid diseases have been detected in various types, and it differed depending on whether polyarteritis nodosa Thus, in patients without extrahepatic complications such as polyarteritis nodosa with acute hepatitis B both autoimmune and allergic disorders were found in 3,1% and in patients with polyarteritis nodosa 6,6% of autoimmune diseases, 9,8% of allergic diseases were noted. As it seems, polyarteritis nodosa is 2,1 and 3,2 times more common in patients with allergic and autoimmune pathologies compared to patients without pathology during acute hepatitis B. Thus, it was revealed that chronic somatic diseases of autoimmune and allergic genesis are risk factors for the development of polyarteritis nodosa in patients with acute hepatitis B. Therefore, it is necessary to discover polyarteritis nodosa in time, to investigate premorbid pathologies, especially paying attention to autoimmune and allergic diseases.