ADHESIONS OF THE ABDOMINAL CAVITY AND HISTOMORPHOLOGICAL CHANGES IN THE SURROUNDING TISSUES IN THE POSTOPERATIVE PERIOD (EXPERIMENTAL STUDY)

Abstract

The article presents the results of a histological analysis of damaged tissues and intraabdominal adhesions created experimentally in rat models. The study was conducted on 90 white outbred rats were divided into 3 groups, with 30 rats in each group: 1) control group - nothing was injected into the abdominal cavity after injury. 2) comparison group - the drug mesogel was injected in an amount of 1 ml. 3) experimental group - an oxygen-enriched mixture of metronidazole + dextran + contrical was injected in a ratio of 1:1:0.1 ml, respectively. Histological analysis of tissues taken in the area of the sutures, peritoneum, damaged segment of the small intestine, liver, and omentum was performed on the 5th, 10th and 21st days. In the control group, a sufficiently developed inflammatory process was observed, while there was almost no inflammatory process in the comparative and experimental groups. The immediate administration of special anti-adhesion medication into the abdominal cavity postoperatively enables the obtainment of positive results.