FIBRINOLYTIC LYMPHOSTIMULATION IN TREATMENT OF DIABETIC ANGIOPATHIES

Abstract

The article gives information on a research done to study of lipid peroxidation disorder, lymph coagulation and lymphatic tissue drainage, their correction in experimental diabetes mellitus.Studies were carried out on 33 rabbits, on a model of diabetes mellitus. In 16 rabbits of the control group, after modeling of alloxane diabetes mellitus, a sucking therapy was performed, and in 17 rabbits of the experimental group, the sucking therapy included intravenous administration of urokinase medac. Simulation of diabetes mellitus in rabbits contributed to increase of clotting potential of lymph with background of activation of lipid peroxidation and reduction of activity of lymph fibrinolysis, with suppression of drainage function of lymphatic system. After administration of urokinase medak, the coagulation potential of the lymph and the intensity of lipoperoxidation were significantly reduced. At the same time, the content of dieneconjugates and malonic dialdehyde was significantly reduced, and during 30 days of the study, markers of activation of intravascular clotting of lymph were not determined. All this was accompanied by a very pronounced increase in the flow rate of lymph from the drained thoracic duct. Thus, the inclusion of urokinase medak in the complex of sugar lowering therapy contributed not only to a marked reduction of clotting potential of lymph and activation of lipoperoxidation, but also very much increased lymphatic tissue drainage.