ЦИТОЛОГИЧЕСКИЙ СТАТУС ШЕЙКИ МАТКИ  ВИЧ-ИНФИЦИРОВАННЫХ ЖЕНЩИН

M.V. Lytvynenko; S.L. Tsevelev; O.L. Koshelnyk; T.Ye. Narbutova; E.S. Buriachkivskyi; O.A. Gulbs; O.M. Nadvorna; V.V. Gargin

doi:10.34921/amj.2022.3.007

Authors

M.V. Lytvynenko Odessa National Medical University
S.L. Tsevelev Odessa National Medical University
O.L. Koshelnyk Odessa National Medical University
T.Ye. Narbutova Odessa National Medical University
E.S. Buriachkivskyi Odessa National Medical University
O.A. Gulbs Pavlo Tychyna Uman State Pedagogical University
O.M. Nadvorna Odessa National Medical University
V.V. Gargin Kharkiv National Medical University

DOI:

https://doi.org/10.34921/amj.2022.3.007

Keywords:

cervix, HIV, CD4

Abstract

The scientific research mentioned in the article was conducted to identify the cytological features of the cervical epithelium and the level of CD4 cells in HIV-infected women. Cytological analysis was performed on 60 reproductive-aged women, they were divided into 2 groups equally. 1^st group consist of HIV-negative, 2^nd group consists of HIV-positive women. When determining low numbers CD4 lymphocytes gradation was performed with 500-350-100 cells per microliter.

This research works results show the acceleration of neoplastic processes of the cervix in HIV-infected women with a decreased number of CD4 cells. It is manifested by inflammatory processes in the smear, koilocytosis, the presence of binuclear and multinucleated cells, keratinocytes, parakeratosis, amphophilic cytoplasm and changes in cervical epithelial cells.

In HIV-infected people, the CD4 cell count below 100 per cubic millimeter should be considered an unfavourable prognostic factor for the development of neoplastic transformation.