THE ROLE OF ADRENERGIC MECHANISMS IN THE FORMATION OF ELECTRICAL ACTIVITY OF BRAIN STRUCTURES UNDER EMOTIONAL STRESS CONDITIONS

Abstract

This article presents a study conducted to investigate, under experimental stress conditions, the cross-correlation relationships and phase shifts of the electroencephalogram waves recorded in the cerebral cortex and subcortical structures, as well as the involvement of adrenergic mechanisms in these processes, in order to examine the functional connections between these structures. The temporal and spatial interrelationships of bioelectrical activity in brain structures were studied in six experimental rabbits using an "NSNeurosoft" electroencephalograph by means of cross-correlation analysis. To create the experimental stress model, the method of electrodermal stimulation of the hind limbs and associated conditioned light signals was employed. To demonstrate the role of the monoaminergic system in the various phases of stress, chlorpromazine was administered intravenously. The results showed that the different phases of stress are accompanied by changes in the reciprocal functional connections between the cerebral cortex and subcortical structures. The partial restoration of the initial functional connections under the influence of chlorpromazine confirms that the pacemaker role of the posterior hypothalamus in the formation of stress is of adrenergic origin.