ЭОЗИНОФИЛЬНОЕ ВОСПАЛЕНИЕ И ВОЗМОЖНОСТИ ЕГО ВЛИЯНИЯ НА ТЕЧЕНИЕ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ КИШЕЧНИКА

G.H. Babayeva; H.I. Ibrahimli; G.V. Asadova; J.S. Musayev

doi:10.34921/amj.2026.1.005

Authors

G.H. Babayeva Azerbaijan State Advanced Training Institute for Doctors named after A.Aliyev https://orcid.org/0000-0002-5805-3741
H.I. Ibrahimli Azerbaijan State Advanced Training Institute for Doctors named after A.Aliyev
G.V. Asadova National Oncology Center of Azerbaijan
J.S. Musayev Baku Pathology Center

DOI:

https://doi.org/10.34921/amj.2026.1.005

Keywords:

eosinophils, inflammatory bowel disease, fibrosis, eosinophil cationic protein

Abstract

This article discusses the results of a study aimed at investigating the impact of eosinophils, particularly eosinophil cationic protein (ECP), on the course of inflammatory bowel diseases (IBD). The study included 446 patients with inflammatory bowel diseases (IBD). Among them, 390 (87.4%) had elevated levels of ECP. In this group of patients, the activity of IBD was more pronounced in laboratory results (indicating high inflammatory activity with high-sensitivity C-reactive protein, platelet levels, homocysteine, fecal calprotectin, and lactoferrin, a decrease in vitamin D and total protein/albumin levels, and high interleukin-10 (IL-10) levels), as well as in endoscopic and morphological indicators. The authors suggest that the determination of ECP levels in the blood should be added to the list of laboratory diagnostic methods, as it may help determine the effectiveness of the response to the baseline therapy administered to IBD patients.