VALUE OF IMMUNOLOGICAL MARKERS IN THE PROGNOSIS OF DEVELOPMENT OF ATOPIC DERMATITIS IN CHILDREN

Abstract

The research work is devoted to the study of the informativeness and specificity of the molecular factors CD31, H4R and IgG1 that are considered important structural components of immunological mechanisms, for the pathogenetic substantiation of cytokinin imbalance, which affects the Th1/Th2 balance as an immune response in the formation of allergic diseases. For the purposes of the study, 528 newborns with gestational age 34-42 weeks were recruited and splitted into the premature and interm newborns groups. Each of these groups, in their turn, were divided into control, comparison and main subgroups. The predictive role of an increase (p<0,05) to a level of 40.8±6.4 pg/ml of the CD31 receptor, which is involved in the regulation of T cell homeostasis from early neonatal age of newborns was confirmed in the formation of atopic dermatitis. Influence on the severity of atopic dermatitis with an increase in IgG1 to 122.0±30.8 ng/ml, changes in the humoral immunological response were noted (p<0,05).