БИОХИМИЧЕСКИЕ ЛАБОРАТОРНЫЕ ДАННЫЕ БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ 2 ТИПА С КОМОРБИДНОЙ ДИСФУНКЦИЕЙ ЩИТОВИДНОЙ ЖЕЛЕЗЫ

M.I.   Marushchak; I.A.  Bandas; T.A. Zaiets; V. Yu. Prokopchuk; I.Ya. Krynytska

doi:10.34921/amj.2022.4.017

Authors

M.I. Marushchak I.Horbachevsky Ternopil National Medical University
I.A. Bandas I Horbachevsky Ternopil National Medical University
T.A. Zaiets I Horbachevsky Ternopil National Medical University
V. Yu. Prokopchuk Rivne Medical Academy of Rivne Regional Council
I.Ya. Krynytska I Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.34921/amj.2022.4.017

Keywords:

type 2 diabetes mellitus, thyroid dysfunction, hypothyroidism, diffuse nontoxic goiter

Abstract

The article presents the results of a study conducted to analyze and compare biochemical laboratory data of type 2 diabetic patients without thyroid dysfunction and type 2 diabetic patients with comorbid hypothyroidism (HT) and/or diffuse nontoxic goiter (DNTG). A retrospective analysis of 596 medical records of T2DM patients was carried out. Serum lipid profile in type 2 diabetes mellitus (T2DM) patients with comorbid HT was characterized by a significant decrease of high-density lipoprotein cholesterol level, as well as an increase of remnant cholesterol and triglyceride levels compared with T2DM patients without thyroid dysfunction, as well as T2DM patients with comorbid DNTG. Biochemical profile data significantly did not differ in T2DM patients without thyroid dysfunction and T2DM patients with comorbid HT and/or DNTG, except aspartate aminotransferase (AST) activity, which was significantly higher in T2DM patients with comorbid HT and DNTG. Moreover, significant direct correlation was observed between serum TSH level and AST activity in T2DM patients with comorbid HT and DNTG.