MICROBIOLOGICAL PECULIARITIES OF THE COURSE AND THERAPY OF UROGENITAL MIXT INFECTIONS IN WOMEN

Abstract

The article presents data from microbiological studies, the purpose of which is to establish the nature of microbiological and immunological disorders in urogenital mixed infections in women and the effectiveness of pathogenetically determined approaches to treatment methods. To achieve this goal, microbiological features of the course of urogenital mixed infections in the reproductive tract of 88 women aged 25 to 38 years caused by a combination of intracellular bacterial flora and mycotic infection: Ureaplasma urealyticum, Micoplasma hominis, Candida albicans, Gardnerella vaginalis were established and a comparative assessment was made the use of a probiotic agent in treatment. Randomization into groups: for the treatment of the following groups of patients were allocated. I group (control group) consisted of 22 healthy women who did not have a pathology. II group (n = 39) is represented by patients with a combination of urogenital infections with U. urealyticum, M.hominis, C.albicans, III group (n=29) – U.urealyticum, G.vaginalis, M.hominis . And IV group (n = 20) – U.urealyticum, M. hominis. Microbiological studies of the urogenital tract revealed the presence of vaginal microbiocenosis disorders in 88 patients with mycoplasmal infections. Staphylococci were most often identified in the examined second and third groups: Staphylococcus epidermidis (38.5% and 34.55%), respectively. And other representatives of the species, in particular, Staphylococcus saprophyticus and S. aureus were detected much less frequently. Only 5 patients with opportunistic infections from the above examination groups isolated representatives of the Streptococcaceae family: Enterococcus spp. – in 7.69% and 6.90% of cases, while in the control group and in the fourth group of patients, these microorganisms were isolated in isolated cases. Analysis of the quantitative content of lactobacilli and bifidobacteria showed a significant increase in the level of seeding and the frequency of seeding of these microorganisms in patients of the second and third groups using probiotic and immunotropic drugs.