FEATURES OF E-CADHERIN EXPRESSION IN THE TRIPLE-NEGATIVE AND LUMINAL “A” PHENOTYPES OF INVASIVE DUCTAL BREAST CANCER

Abstract

The article presents the results of a study conducted to assess the features of E-cadherin expression in the development and progression of invasive ductal breast cancer.

A general histological, immunohistochemical and morphometric study of triple-negative and luminal "A" phenotypes of invasive ductal breast cancer was carried out. E-cadherin expression was assessed semi-quantitatively using the Qureshi scoring system. Comparison of E-cadherin expression in various clinical and pathological parameters was assessed using Pearson's χ2 test. For all types of analysis, differences were considered significant at p <0.05.

We found that high expression of E-cadherin was more often observed in ER-positive tumors, in 16 (64.00 [44.60-81.28] %, p=0.048) of 25 patients with luminal "A" carcinoma phenotype predominantly aged >50 years. Triple-negative breast cancer was characterized by a significant predominance of patients with low and negative E-cadherin expression (p=0.011). In 14 (70.00 [48.66-87.56] %) out of 20 cases, low cell adhesion values were determined, although the majority of patients were older than 50 years (p=0.050). In 30% of patients, a high expression of E-cadherin was observed, mainly in the age group over 50 years (p=0.050). Low expression of E-cadherin or its absence was associated with pT3 tumors, 3 clinical stages of the disease, with grades G2 and G3.