DALAĞIN ZƏDƏLƏNMƏLƏRİNİN CƏRRAHİ MÜƏLİCƏSİNDƏN SONRA HUMORAL İMMUNİTETİN DƏYİŞİKLİKLƏRİ

J.N. Hajiyev; N.J. Hajiyev; I.A. Abdullayev; M.N. Tarverdiyev; S.H. Gasimova

doi:10.34921/amj.2026.2.007

Authors

J.N. Hajiyev Department of General Surgery, Azerbaijan Medical University
N.J. Hajiyev Department of General Surgery, Azerbaijan Medical University
I.A. Abdullayev Department of Clinical Disciplines and Military Medicine, Nakhchivan State University, Faculty of Medicine
M.N. Tarverdiyev Department of Clinical Disciplines and Military Medicine, Nakhchivan State University, Faculty of Medicine
S.H. Gasimova Department of General Surgery, Azerbaijan Medical University

DOI:

https://doi.org/10.34921/amj.2026.2.007

Keywords:

spleen, splenectomy, organ-preserving interventions, humoral immunity

Abstract

The article presents a study conducted for the purpose of investigating the state of humoral immunity in patients who underwent surgical treatment for splenic injuries. The study enrolled 49 patients who had sustained splenic injury. Of the 49 patients, 35 (Group I) underwent splenectomy, while 14 underwent various organ-preserving interventions. Fifteen practically healthy individuals were included in the control group. Before surgical treatment and in the early postoperative period – on days 1-3, 5-7, and 10- 14 – immune parameters (CD19+, IgA, IgM, and IgG), the concentration of circulating immune complexes, the total concentration of complement, and the C3 fraction were investigated in the patients' blood. The studies conducted demonstrated that profound changes occur in humoral immunity in the early postoperative period following splenectomy. In patients who underwent organ-preserving interventions, the changes arising in humoral immunity were found to be less pronounced compared with patients whose spleen had been removed.