IMPORTANCE OF EFFERENT AND ENZYME THERAPY IN THE TREATMENT OF GENERALIZED PURULENT PERITONITIS

Abstract

The aim of the study was to prove the role of cytokines and antimicrobial peptides based on pathogenetic changes in the results of treatment of widespread purulent peritonitis with efferent and enzyme therapy. The 97 patients in the main group were divided into 3 groups according to the principles of treatment. In accordance with the treatment regimen, the patients were divided into 3 groups. Group I (32 patients) receiving classical treatment, Group II (32 patients) receiving plasmapheresis in addition to classical treatment, and Group III group (33 patients) receiving cryopheresis, extracorporeal and intravenous ultraviolet, extracorporeal infrared, laser radiation - intravenous and enzyme therapy in addition to those used in group II. The control group consisted of 16 healthy people. In addition to classical treatment and plasmapheresis, group III patients underwent cryopheresis, extracorporeal as well as intravenous ultraviolet, extracorporeal infrared and intravenous laser irradiation, intravenous autoplasm, antibiotics (Polsipro) and immunocorrectors (Roncoleukin ril2, İmmunofan).

 Also, in group III patients, 15 tablets of wobenzyme were crushed and mixed with colloidal starch and injected into the intestinal tract through a transnasal enteral feeding tube kept in the patient's small intestinal loop during surgery. Treatment outcomes were evaluated based on changes in patients' blood levels of cytokines and antimicrobial peptides. In the group of complex treatment measures, 92% (p<0.05) showed positive results in patients, the patient's condition stabilized early and rapid recovery was observed.