КЛИНИЧЕСКИЕ ОСОБЕННОСТИ ТЕЧЕНИЯ ОСТРОГО ГЕПАТИТА B ПРИ НАЛИЧИИ ХРОНИЧЕСКИХ ПЕРСИСТИРУЮЩИХ ИНФЕКЦИЙ РАЗЛИЧНОЙ ЭТИОЛОГИИ

G.Z. Aliyeva; H.A. Kadirova; S.V. Hajiyeva; G.F. Vekilova; A.B. Allahverdiyeva; V.N. Javadzade

doi:10.34921/amj.2026.2.004

Authors

G.Z. Aliyeva Department of Medical Microbiology and Immunology, Azerbaijan Medical University
H.A. Kadirova Department of Medical Microbiology and Immunology, Azerbaijan Medical University
S.V. Hajiyeva Department of Medical Microbiology and Immunology, Azerbaijan Medical University
G.F. Vekilova Department of Medical Microbiology and Immunology, Azerbaijan Medical University
A.B. Allahverdiyeva Department of Medical Microbiology and Immunology, Azerbaijan Medical University
V.N. Javadzade Department of Infectious Diseases, Azerbaijan Medical University

DOI:

https://doi.org/10.34921/amj.2026.2.004

Keywords:

acute and chronic hepatitis B, gram-positive and gram-negative bacteria, Candida infections

Abstract

The article presents the results of an examination of 132 patients with acute hepatitis B (mild and moderate forms), of whom 79 had chronic persistent infections, demonstrating a significant impact of underlying infectious pathology on the course and prognosis of the disease. In patients with mild hepatitis on the background of chronic infection, gram-positive bacteria predominated (73.7%), whereas in moderate cases, underlying infections were more often caused by gram-negative bacteria and Candida spp. Six to eight months after the disease, the rate of chronicity of acute hepatitis B was 9.1%, with the highest risk of progression to the chronic form observed in patients with mild hepatitis on the background of gram-positive microbiota. These findings indicate that premorbid conditions significantly influence the clinical course of acute hepatitis B: local infections caused by gram-negative bacteria and Candida are associated with a more severe course but a lower rate of chronicity compared to gram-positive bacterial infections.