MODERN ASPECTS OF THE PATHOGENESIS OF ACUTE PANCREATITIS

Abstract

This article presents the results of an experimental study aimed at investigating the pathogenetic mechanisms of acute pancreatitis. The experimental research was conducted using a newly developed experimental model of acute pancreatitis on 48 rabbits of the "Chinchilla". The proposed new experimental model of acute pancreatitis was created by introducing a special complex, consisting of a mixture of bile and chloroform (in 2:1 ratio) into the pancreatic tissue of “Chinchilla” rabbits at a dosage of 5-10 mg per 100 g of rabbit weight. The introduction of bile and chloroform into the pancreatic tissue by a syringe with a thin needle was performed in various places to a depth of 1-3 mm, total dose of 0,3-0,5 ml. In this case bile induces inflammation, while chloroform causes necrosis, which allows to create a mixed form of acute experimental pancreatitis. Morphological studies have established that pathological activation of autoenzymes in the parenchima and ductal system of the pancreas performs only an alteration function, while the leading role in the pathogenesis of the development and outcome of this pathology belongs to progressive disturbances of intraorgan microcirculation. It has been established that on the third day of the disease occurs a blocade of the microhemocirculation of the pancreatic parenchyma and simultaneously happens the activation of the drainage and transport function of its microlymphcirculation. This fact explains the low clinical effectiveness of conservative treatment of patients with acute pancreatitis, carried out by traditional methods (i/v, i/m) and serves as a therapy in this category of patients for delivering drugs to the site of inflammation and destruction.