FEATURES OF ANTIBIOTIC ACCUMULATION IN APPENDIX DEPENDING ON THE METHOD OF ADMINISTRATION AND BLOOD SUPPLY

Abstract

The features of antibiotic (ceftriaxone) accumulation in the appendix were studied, depending on the methods of its administration.

The study included 160 patients Ukrainian population with acute appendicitis. The patients were divided into three groups. The first group of patients was injected with an antibiotic intramuscularly, the second group – intravenously, the third group – lymphotropically. Each of the groups was subdivided into two subgroups (A and B), one of them (A) the drug was administered 1 hour before the operation, the second (B) – 2 hours before the operation. The essence of the lymphotropic technique consisted in the regional administration of drugs that stimulate lymphatic secretion, antispasmodics, anticoagulants, anti-inflammatory drugs, and an antibiotic. After the operative removal of the appendix a homogenate was prepared, added to agar-agar, on which E. coli was grown. A day later, the zone of inhibition of E. coli growth was fixed, which indirectly confirmed an antibiotic in this zone. The specimens of patients with phlegmonous, gangrenous, and gangrenous-perforated appendicitis were studied. In the control sample, pure antibiotic was added to agar-agar.

After intramuscular injection, zones of growth inhibition of E. coli were not detected. After intravenous antibiotic injection, the zone of growth inhibition of E. coli was recorded in all samples of the added homogenate, with the exception of 17 (33,3%) samples of the distal part the appendix. After lymphotropic injection of the antibiotic, the growth retardation of E. coli was in all samples, not differing from the control, which determines the accumulation of the antibiotic in all parts of the appendix in in sufficient quantity to retard the growth of the E. coli culture.