EFFECTS OF VARIOUS IMPLANT TYPES ON ABDOMINAL WALL TISSUE: AN EXPERIMENTAL STUDY

Abstract

The research studied the reaction of peritoneal tissue and the muscular aponeurotic layer of the anterior abdominal wall to a polypropylene implant treated with the antibiotic tyrothricin. The studies were conducted in the laboratory of the Dnieper Medical University clinic during 2022-2023. on 20 mature male Wistar rats weighing 200-240 g. The rats were divided into 4 groups of 5 animals each. An experimental study revealed the integration of tissue elements of the peritoneal walls and the muscular aponeurotic layer of the abdominal wall with the material of polypropylene mesh. At the same time, active processes of collagenogenesis occurred in the border zones and the area of integration with the implant, as well as pronounced manifestations of vascularization of the connective tissue. The morphological features of the connective tissue formed in the area and around intact implants and meshes treated with tyrothricin did not differ significantly from each other, which indicates the positive biocompatibility of body tissues and polypropylene implants.