NEOGENESIS OF LYMPHOID NODULES OF SMALL INTESTINE OF WHITE RATS INDUCED BY A BROAD-SPECTRUM ANTIBIOTIC

Abstract

The article presents the results of a study conducted to investigate the neogenesis of lymphoid nodules in the small intestine of rats induced by a broad-spectrum antibiotic. The study was conducted on 60 white male rats of reproductive age, weighing about 200.0±20.0 grams, which were divided into two groups: control (n=30), and animals of the second group (n=30) in which studied the morphological state of the group lymphoid nodules of the small intestine after the clarithromycin administration. The genetically programmed total number of group lymphoid nodules in the small intestine of rats is a constant, while the number of lymphoid nodules in them is a variable value that depends on situational shifts in the microbiocenosis of the small intestine. Group lymphoid nodules are characterized by a large degree of individual variability in the number of lymphoid nodules involved in immune reactions, which depends on the variability of the antigenic composition of the contents of the small intestine. Thus, lymphoid formations of the mucous membrane and submucosa of the small intestine of white rats are newly formed (initial) forms of group lymphoid nodules, the appearance of which can be explained by a violation of microbiocenosis in the small intestine under the influence of a broad-spectrum antibacterial drug - clarithromycin, which also has immunotropic properties. After taking an antibiotic, we observed the phenomena of working, compensatory hyperplasia of genetically determined lymphoid structures, which are related to secondary (peripheral) organs of the immune system.