LIVER DAMAGE IN PATIENTS WITH ACUTE BRUCELLOSIS

Abstract

The article presents the results of determining clinical, laboratory, and functional changes in the liver of patients with acute brucellosis. Considering the contradictory data in the examination of different populations and the lack of alertness regarding liver damage in acute brucellosis, the purpose of our study was to determine clinical, laboratory, and functional changes in the liver that occurred in cases of acute brucellosis in the Republic of Azerbaijan. 120 patients with suspected brucellosis who sought medical help at the Baku Clinic and the Central Clinical Hospital of Baku were examined. To assess the condition of the liver, all patients underwent biochemical studies with mandatory determination of the levels of total bilirubin, ALT, AST, ALP, GGT, and LDH. Ultrasound diagnostics of the abdominal organs was also carried out on a Voluson E8 General Electric device using a volumetric 4D convex multifrequency sensor 4 - 8 MHz RAB 4-8D. Thus, the ALT level was 1.9 times higher in the main group than in the control group, and the AST level was almost 2.5 times higher (Table 1). The higher level of AST in our patients may be due to the high incidence of cardiovascular system (CVS) diseases and according to our study, namely 77.50%. Among patients with brucellosis, a normal ALT level was significantly (p <0.05) more often recorded, namely in 64.15% (77 patients), while an elevated level was recorded in 35.83% (43 patients). AST levels above normal were recorded in 40.00% (48 patients) and normal levels in 60.00% (72 patients) of patients. Thus, biochemical and ultrasound studies revealed lesions of the liver and spleen in patients with acute brucellosis, namely hepatitis, liver cyst and spleen abscess. Signs of chronic non-calculous cholecystitis were also detected in 1 patient. Brucellosis is a multisystem disease affecting the liver and spleen. The frequency of detection of hepatomegaly was 40.83%, splenomegaly - 47.50%. The main changes in the biochemical analysis are an increase in ALT and AST (35.83% and 40.00%, respectively). In acute brucellosis, signs of acute hepatitis are most often found.