THE MORPHOLOGICAL FEATURES OF SIALOLITHIASIS IN THE CONTEXT OF BENIGN AND MALIGNANT TUMORS OF THE SALIVARY GLAND

Y. Kuzenko; O. Diachenko; S. Danylchenko; R. Moskalenko; I. Tkachenko; K. Sikora; O. Antonov; A. Piddubnyi; O. Kuzenko

doi:10.34921/amj.2024.1.024

Authors

Y. Kuzenko Medical Institute, Sumy State University
O. Diachenko Medical Institute, Sumy State University
S. Danylchenko Institute of Applied Physics of National Academy of Science
R. Moskalenko Medical Institute, Sumy State University
I. Tkachenko Medical Institute, Sumy State University
K. Sikora Medical Institute, Sumy State University
O. Antonov Sumy Regional Clinical Dental Polyclinic
A. Piddubnyi Medical Institute, Sumy State University
O. Kuzenko Medical Institute, Sumy State University

DOI:

https://doi.org/10.34921/amj.2024.1.024

Keywords:

salivary gland, benign tumour, malignant tumour, parotid gland, sialolithiasis, calcification, calculus, scanning electron microscopy (SEM)

Abstract

The article provides information ab\out research conducted to identify the factors causing the formation of stones in salivary glands. The study utilized 20 tissue samples from salivary glands, encompassing both benign and malignant tumors with biomineral formations. For a more profound understanding of the pathogenesis of calcifications in structurally altered tissues, histological, immunohistochemical analyses (utilizing markers for acute and chronic inflammation, as well as to detect the initiation of apoptosis), and microelement analysis of sialoliths were conducted.
It was found that the formation of sialolithiasis in the presence of a tumorous process occurs due to structural tissue rearrangement amid inflammatory processes, changes in pH levels, and mineral deposition in a specific sequence.