CHANGES IN IMMUNOGLOBULIN CONCENTRATIONS IN THE BLOOD SERUM OF PATIENTS WITH ACUTE HEPATITIS B COMPLICATED BY POLYARTERITIS NODOSA

Abstract

The article provides information on the quantitative changes in the main classes and subclasses of immunoglobulins in the examinations performed to assess humoral immunity in patients with acute B virus hepatitis complicated by polyarteritis nodosa. The study included 61 patients with nodular polyarteritis complications and 97 patients without such complications, a total of 158 acute B virus hepatitis patients and 30 practically healthy individuals as controls. The concentration of immunoglobulins in the blood serum of patients was determined by enzyme-linked immunosorbent assay.
An increase in the level of immunoglobulins of all classes was noted in patients with acute hepatitis B virus. The highest level of total IgG was found in patients with polyarteritis nodosa, which was significantly higher than the control group (p<0.05). An increase in the level of IgG4 was also noted. Thus, in patients with nodular polyarteritis, it was determined that, in addition to the control group, it was significantly higher than the indicators of patients with acute B virus hepatitis not complicated with nodular polyarteritis (p<0.05). Also, the amount of IgE was higher in the control group and in patients with acute B virus hepatitis complicated by nodular polyarteritis without such complication (p<0.05). Thus, changes in humoral immunity in patients with acute B virus hepatitis complicated by nodular polyarteritis were characterized by a significant increase in the levels of IgG, IgG4 and IgE in the blood. Such changes can be associated with the influence of premorbid background pathologies - autoimmune and allergic diseases - usually observed in patients with acute hepatitis B.