CLINICAL FEATURES OF MIGRAINE IN ANTIPHOSPHOLIPID SYNDROME AND GENETIC THROMBOPHILIA

Abstract

The article presents the results of a study aimed at establishing the clinical features of migraine in the presence of antiphospholipid syndrome (APS) and genetic thrombophilia (GT).
Inclusion criteria comprised 55 women diagnosed with migraine, with or without aura. Among them, 23 were allocated to the study group (presenting with concurrent APS or GT), while the remaining 32 formed the control group (lacking APS and GT comorbidities). The assessment encompassed clinical evaluations, obstetric-gynecological examinations, and comprehensive family histories. Additionally, neuropsychological assessments were performed using the Beck scale and Spielberger scale.
In the cohort of migraine patients within the APS/GT context, notable distinctions were observed when compared to the control group. These distinctions encompassed an earlier onset of migraine (p = 0.006), a reduced frequency of migraine attacks (p < 0.0001), an elevated prevalence of obstetric pathologies, including early spontaneous abortion (p = 0.023), fetal growth restriction (p = 0.0006), and recurrent pregnancy loss (p < 0.0001). Additionally, individuals in the APS/GT group exhibited diminished scores in both reactive (p = 0.04) and personality anxiety (p = 0.038), highlighting the distinctive clinical attributes associated with the co-occurrence of APS or GT in migraine patients. An early manifestation of migraine, coupled with a low attack frequency, elevated prevalence of obstetric pathologies, and the absence of pronounced comorbid anxiety disorders, possibly can be as a markers for migraine associated with hypercoagulation syndrome.