FIBROLAMELLAR HEPATOCELLULAR CARCINOMA

Abstract

The article presents the case report of a patient with fibrolamellar hepatocellular carcinoma (FL-HSC) and a review of the literature on FL-HSC. In the pathological examination of a biopsy taken from the mass of the right lobe of the liver of a 37-year-old man, tumor cells located within lamellar fibrosis were found. Immunohistochemically, tumor cells were positively stained with antibodies to PanCK, cytokeratin 7, CD68, carbonic anhydrase IX, and glutamine synthetase. In the absence of vimentin staining, sinusoidal capillarization by CD34 and focal canalicular staining by CD10 were identified. The patient was diagnosed with FL-GSC, a right-sided lobectomy was performed, and the first diagnosis was confirmed by pathological examination of the removed tumor.
Epidemiological, clinical, radiological, pathological, immunohistochemical and molecular features of FL-HCC are noted. FL-HCC is considered a histological variant of HCC due to its distinct morphological and clinical features. Patients with FL-HCC who undergo liver resection have a significantly higher 5-year survival than patients with the non-fibrolamellar subtype of hepatocellular carcinoma. According to the authors, it is important to compare the effectiveness of liver resection and liver transplantation in patients with FL- HCC in future studies.