CHANGES IN THE MORPHOFUNCTIONAL PROPERTIES OF CARDIOMYOCYTES AFTER ACUTE PHYSICAL LOAD

Abstract

This article presents the results of research conducted to study the ultrastructural changes in cardiomyocytes after extreme acute physical load in an experiment. In the experiment, white laboratory male rats of sexually mature age, with an initial body weight of 120.0-140.0 grams were used. Physical loads were reproduced on a rotating wheel with a diameter of 0.5 m. During the study, 30 rats were used, 6 of which were the control group. Animals were subjected to a single physical load by running for 3 hours on a rotating wheel until they were completely exhausted. Histological, electron histochemical, and ultramicroscopic research methods were used to study the changes that appeared in the myocardium. The study showed that during an acute load in experimental animals in the myocardium, the light-optical system failed to detect serious changes, and hydration of the connective tissue stroma was observed. An electron microscopic examination of the ventricular myocardium showed that early changes in it are inextricably linked with the state of the capillary ultrastructure. In the wall of capillaries, dystrophic processes of various intensities occur, which have an uneven focal character, the ultrastructure of endothelial cells and the cytomembrane of their membranes undergo significant changes. The picture of edema of myocardial muscle tissue, as a rule, is due to a significant restructuring of the myocyte structures, which is recorded electron-microscopically.