PARAMETERS OF MITOCHONDRIAL AND MICROSOMAL OXIDATION IN THE LUNGS OF RATS HAVING CHEST INJURIES AND DIABETES MELLITUS, AND THEIR CORRECTION

Abstract

The article deals with the issue of the effectiveness of the use of emoxipin by determining the production of superoxide anions of mitochon drial and microsomal origin in the treatment of experimental diabetes mellitus and chest injuries on 25 white outbred male rats, which were divided into 3 groups: the first group – control (5 rats), the second experimental group – with chest trauma and diabetes mellitus (10 rats) and the third experimental group - with chest trauma, diabetes mellitus and correction with emoxipin (10 rats). Observations were carried out on the 1st, the 14th and the 28th day. It was found that the increase in the total level of superoxide anion radical in lung tissue occurred mainly due to its mitochondrial production, reaching a maximum in the lungs on the 14th day of the experiment, which confirms mitochondrial dysfunction when free radical oxidation is activated in the lungs in diabetes mellitus and injuries. Comparing the indicators of microsomal and mitochondrial oxidation of the experimental groups, the expediency of using emoxipin to reduce the intensity of oxidative stress development has been proved.