PATHOMORPHOLOGY OF KIDNEYS INTRAMURAL NERVOUS APPARATUS IN CHRONIC RENAL DISEASE DEVELOPING ON THE BACKGROUND OF IDIOPATHIC ARTERIAL HYPERTENSION

Abstract

Morphological changes in the kidney tissues were studied in 8 patients with hypertensive nephropathy who died from terminal renal and heart failure (5 and 3, respectively) by using histological and histochemical methods, . The control group consisted of 5 practically healthy individuals who died as a result of a car accident. For histological examination, pieces of renal plexus tissues after fixation in 12% solutions of neutral formalin were stained with hematoxylin and eosin, picrofuccin according to Van Gieson, according to the Nissl method, and impregnated with silver nitrate salts according to the Bilshovsky-Gross method.
Adrenergic nerve structures were performed by incubation of sections in a 2% solution of glyoxylic acid, and cholinergic elements by the Karnofsky-Roots method. The preparations were investigated under a microscope ML-2.
It was revealed that in chronic renal disease developing on the background of idiopathic arterial hypertension, in the structural elements of the renal nerve elements, along with degenerative changes, there are also compensatory-adaptive processes that ensure the restoration of lost connections. It was found that there is a decrease in mediators in the nerve plexuses of the kidney. It was found that in hypertensive nephropathy, reactive-compensatory changes in the structural elements of the renal nervous system are not accompanied by the restoration of the initial level of mediators.