THE IMPACT OF CARDIAC REHABILITATION ON ENDOTHELIAL DYSFUNCTION IN CORONARY ARTERY DISEASE

Abstract

The article provides information about the impact of cardiac rehabilitation on the functional state of the vascular endothelium in individuals with coronary artery disease. The study included 87 patients, with 57 patients undergoing cardiac rehabilitation assigned to group I, and patients who did not undergo cardiac rehabilitation assigned to group II. At the beginning of the study, blood levels of En-1 and NO were determined in both groups, and flow-mediated dilatation was measured. After 10 weeks of the cardiac rehabilitation program, group I showed a significant increase in flow mediated dilatation (FMD) (p=0.013). In group II, the increase in FMD was 11.2±0.19%, but it did not reach statistical significance (p=0.092). The findings suggest that a 10-week cardiac rehabilitation program can lead to a positive improvement in endothelial function and lipid metabolism in patients with coronary artery disease. The results indicate that exercise therapy may be an effective clinical strategy to prevent cardiovascular complications in these individuals. However, it is important to note that further large-scale research is needed to obtain more accurate and comprehensive information in this area.