ASSOCIATION OF THE β-FIBRINOGEN G/A-455 POLYMORPHISM WITH LIPID METABOLISM IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

The article presents the results of a study conducted to elucidate β-fibrinogen G(-455)A polymorphisms and their relationship with lipid parameters in patients with arterial hypertension (AH). The study included 100 patients. Each patient underwent measurements of anthropometric parameters, complete blood count, lipid profile, blood sugar and/or HbA1C, fibrinogen gene, and electrocardiographic and echocardiographic studies. In the studied groups with hypertension (group I), hypertension and ischemic heart disease (IHD) (group II), hypertension, IHD, and type 2 diabetes mellitus (group III), and in patients in the control group, the prevalence of the homozygous G/G genotype of FGB G (-455) A gene was noted. In patients with hypertension, compared with the control group, there was an increase in the levels of total cholesterol, triglycerides, very low-density lipoproteins, low-density lipoproteins, an atherogenic index, and a decrease in high-density lipoproteins (p>0.05). An elevated atherogenic index reflects impaired cholesterol metabolism, and in our study, a high atherogenic index was found in 55.2% of patients in the AH group. Based on our findings, hypertriglyceridemia was diagnosed in 51.7% of patients with AH. No statistically significant relationship was found between lipid parameters and FGB G (-455) A gene genotype variants.