CLINICAL AND IMMUNOLOGICAL ASPECTS OF THE TREATMENT OF CHRONIC WOUNDS USING VAC-THERAPY

I.V. Korpusenko; N.N. Nor; V.P. Kryshen; N.V. Trofimov; V.E. Kudryavtseva; B.V. Guzenko; A.N. Makarenko; A.N. Kyrychenko

doi:10.34921/amj.2023.3.008

Authors

I.V. Korpusenko Dneprovsk State Medical University
N.N. Nor Dneprovsk State Medical University
V.P. Kryshen Dneprovsk State Medical University
N.V. Trofimov Dneprovsk State Medical University
V.E. Kudryavtseva Prydniprovskuy State Academy of Physical Culture and Sport
B.V. Guzenko Dneprovsk State Medical University
A.N. Makarenko Interregional Academy of Personnel Management
A.N. Kyrychenko Ukrainian State University of Chemical Technology

DOI:

https://doi.org/10.34921/amj.2023.3.008

Keywords:

chronic wound, VAC-therapy, surgical treatment, wound healing process, immune system

Abstract

The article presents the results of a study conducted to improve treatment effectivenes of patients with chronic wounds of the lower extremities by using of complex treatment, which included VAC (Vacuum Assisted Closure) therapy, surgical treatment and hyaluronic acid preparations. The 52 patients with chronic wounds of the lower extremities were examined. Mostly they are women (48) aged 45-75 years. Evaluation of the treatment effectiveness was based on the study of clinical indicators of wound healing, microbiological studies and immunological data. Complete wound healing was achieved in all patients. In 67% of patients, the transplanted audoderm graft engrafted completely. In 28%, partial lysis was observed, which required repeated operations. In 3% of the wounds healed without surgery.
A modern integrated approach can radically solve the problems of chronic wound healing, as evidenced by a decrease in the B-cell link of immunity against the background of an adequate increase in T-helpers and restoration of the balance between T- and B- cellular links with normalization of the CIC.