CORRECTION OF IMMUNOLOGICAL INDICATORS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B

Abstract

The article provides information on the immunological indicators of patients with chronic viral hepatitis B and their correction using Kroven medication, which belongs to the group of immunomodulators. Immunological indicators of 22 patients diagnosed with viral hepatitis B were studied before and after treatment. The concentration of T and B-lymphocytes, as well as immunoglobulins (IgA, IgM, and IgG) in the blood, was significantly lower before treatment, which is considered one of the major causes leading to the chronicity of the pathological process. It was observed that the use of the immunomodulator Kroven 5%-50.0 in the complex treatment of patients diagnosed with viral hepatitis B, in addition to restoring immunological indicators, prevents complications with secondary bacterial microflora. Only 4 patients (18.1%) had a high viral load (greater than 1.2 x 108 copies/ml) and were prescribed Vikure (Entecavir) – 1 mg, which is included in the group of antiviral medications. Although the other patients were not prescribed antiviral medication, their immunological parameters after treatment were higher than normal. The presence of immunological indicators (T, B-lymphocytes, IgA, IgM, and IgG) within the norm helps to restore the clinical and laboratory indicators of patients.