CLINICAL AND GENETIC FEATURES OF STROKE IN CHILDREN OF THE UZBEK POPULATION

Abstract

The article presents the results of a clinical and genetic study of children with various types of strokes. The study included 200 children. The main group included 103 patients (72 boys and 31 girls) aged 0-18 years. The control group consisted of 97 conditionally healthy children (68 boys and 29 girls) of the same age, without a history of neurological or thromboembolic diseases. According to the diagnosis, 103 patients with ONMC were divided into 3 subgroups: IS - 48 children, HS -36 children and HT -19 patients. The data obtained indicate the absence of a statistically significant relationship between the polymorphism of the genes PAI-I 675 5G/4G, FII 20210 G/A and FV 1691 G/A. However, there was a tendency to accumulation of the 4G allele and 4G/5G genotype of the PAI-I gene and the G allele of the VEGF gene (G634C) in the group of children with HT type of stroke. As for the polymorphism of the MTHFR gene, according to the data obtained, there is a clear link between the carrier of the T allele and the development of stroke in children.