IMPROVEMENT OF DIFFERENTIAL DIAGNOSIS OF INFECTIOUS MONONUCLEOSIS OF HERPES VIRUS ETIOLOGY

Abstract

The article presents the results of a comparative analysis of clinical and laboratory data of patients with infectious mononucleosis caused by viruses of the herpes family IV and V types. The surveyed contingent consisted of children aged 1 to 15 years. To make a diagnosis, the polymerase chain reaction method was used to identify the DNA of the pathogen in blood serum, saliva and urine. The enzyme immunoassay method was used to determine separately specific antibodies of the IgM and IgG classes to antigens of herpes types IV and V. It was shown that patients with infectious mononucleosis caused by herpesvirus type IV and with mixed infection (EBVI + CMVI) are characterized by more pronounced lymphoproliferative syndrome, high fever, tonsillitis with overlaps and a positive test for heterophile antibodies (in 57.9% of cases and 50%, respectively). The clinical picture of infectious mononucleosis of cytomegalovirus etiology was characterized by moderately severe fever, lymphoproliferative syndrome, the presence of catarrhal tonsillitis and the absence of a positive reaction to heterophile antibodies.