PREDICTING THE PROBABILITY OF DEVELOPING OVARIAN HYPERSTIMULATION SYNDROME IN INFERTILE WOMEN DURING IN VITRO FERTILIZATION

Abstract

The article presents the results of a study conducted to develop an optimal model for predicting the probability of ovarian hyperstimulation syndrome in infertile women in the program of assisted reproductive technologies. The object of the study was women with infertility (primary and secondary) referred for infertility treatment by in vitro fertilization (IVF/ICSI) at the Central Clinical Hospital in Baku. The retrospective part of the work consisted of a study of 518 infertile patients who underwent 690 cycles of IVF ICSI. According to the results of IVF-ICSI, all patients were divided into two groups: patients with pregnancy - A - group - main (234 women) and patients with negative IVF ICSI attempts - B - control group (284 women), who after the IVF procedure - ICSI pregnancy did not occur. At the prospective stage of the work, women who underwent IVF/ICSI treatment were divided into two subgroups (presence of complications during ovulation stimulation - ovarian hyperstimulation syndrome - OHSS) - 1st subgroup (55 women) and without complications (without OHSS) - 2nd subgroup (69 women). The data obtained from clinical and laboratory studies were processed by the methods of variation statistics in the statistical analysis system STATISTICA 10. The main predictors of OHSS development during IVF procedures in infertile women are age, body mass index (BMI), antral ovarian follicle number (AOF), polycystic ovary syndrome (PCOS) and antimullerian hormone (AMH). Informative predictors of the likelihood of developing OHSS during IVF procedures in infertile women are age, BMI, AOF, PCOS and AMH, while age and BMI are negatively associated with the likelihood of developing OHSS, and an increase in the AOF of the left and right ovaries, the level of AMH and PCOS – are positively associated with the likelihood of developing OHSS during IVF.