ANALYSIS OF IRON METABOLISM AND SOME IMMUNE PARAMETERS IN THE DYNAMICS OF TREATMENT OF CHILDREN WITH IRON DEFICIENCY ANEMIA

Abstract

The article presents the results of a study conducted for comparative analysis of hematological, iron deficiency, and some immune parameters before and after treatment with iron preparations in children aged 6 months to 5 years with iron deficiency anemia (IDA) of varying severity. The study included 63 children, with 35 children diagnosed with IDA (main group), and 28 healthy children were included in the control group. The results of the study showed that before treatment the indicators of iron metabolism (hemoglobin, hematocrit, color index, iron in blood serum, ferritin in blood serum, total iron-binding capacity of serum, latent iron-binding capacity of serum, transferrin saturation coefficient and etc.) were lower in IDA group compared to the control group. Additionally, both innate (NK-CD56+) and acquired (CD3+, CD4+, CD8+) components of cellular immunity were also decreased in the IDA group compared to the control group. After 8-16 weeks of oral treatment with iron-containing drugs (aktiferrin, totema, ferrum lek), the levels of iron in the blood and relative numbers of cellular immunity indicators increased in the IDA group compared to their pre-treatment levels and approached the levels seen in the control group. This finding highlights the effectiveness of treatment in preventing future complications associated with IDA.