FEATURES OF CHANGES IN HORMONES IN GIRLS WITH CENTRAL PRECOCIOUS PUBERTY

Abstract

The results of a study aimed at investigating the hormonal status of girls with central precocious puberty are presented. According to the results of clinical, hormonal, functional, radiological research methods, 31 (83.8%) of 37 examined girls were diagnosed with central precocious puberty. The comparative group consisted of 27 girls with a physiological course of puberty. The average age of girls with CPP of was 9.9±0.8 (6-12) years. Girls' weight was 43.3±0.8 (40-60) kg, height 148.0±0.16 (140-158) cm. Serum hormones: prolactin (Prl), estradiol (E2), testosterone (T), dehydroepiadosterone sulfate (DHEAS), cortisol (C), and indicators of the functional activity of the thyroid gland: triiodothyronine (T3) and thyroxine (T4) were detected by the method of hemoluminescence. It was established that the mothers of girls with CPP had obstetric complications during childbirth, including primary and secondary weakness of labor activity, absence of labor activity on the background of premature rupture of amniotic fluid, stimulation and induction of labor activity, macrosomic fetus, acute intranatal fetal hypoxia, newborn asphyxia. In subsequent periods of the girls' lives, the presence of neurological symptoms was noted. The girls were observed by a neurologist. According to the X-ray and MRI examinations, the absence of organic brain lesions was established and precocious puberty was predominantly idiopathic. It was found that girls with CPP showed a significant increase in LH (16.13±0.97 mIU/ml), estradiol (166.5±4.38 pg/ml) (P<0.05), which reflected increased functional activity of the hypothalamic-pituitaryovarian system.