КОРРЕЛЯЦИИ МЕЖДУ МОРФОМЕТРИЧЕСКИМИ ПОКАЗАТЕЛЯМИ АТРОФИИ ГОЛОВНОГО МОЗГА И КЛИНИЧЕСКОЙ СИМПТОМАТИКОЙ ПРИ РАССЕЯННОМ СКЛЕРОЗЕ

R.K.  Shiraliyeva; А. Memish; A.H. Mirzayev; R.R. Aliyev

doi:10.34921/amj.2020.2.007

Authors

R.K. Shiraliyeva Azerbaijan State Advanced Training Institute for Doctors named after A.Aliyev
А. Memish Republican Medical Diagnostic Center
A.H. Mirzayev Azerbaijan State Advanced Training Institute for Doctors named after A.Aliyev
R.R. Aliyev Azerbaijan State Advanced Training Institute for Doctors named after A.Aliyev

DOI:

https://doi.org/10.34921/amj.2020.2.007

Keywords:

multiple sclerosis, brain atrophy, clinical features, correlation

Abstract

The article presents the results of a study conducted to explore the correlation between morphometric indicators оf brain atrophy and clinical symptoms in multiple sclerosis (MS). 88 patients (58 women, 30 men) with MS aged 18 to 60 years were under observation. 56 patients had relapse-remitting multiple sclerosis (RRMS), 32 patients had a secondary progressive multiple sclerosis (SPMS) type of disease course. All patients underwent magnetic resonance imaging with voxel morphometry. It was found that in patients with MS, despite pronounced changes in white matter, the degree of disability depends on the severity of brain atrophy and is not related to the volume of focal lesion. There are significant relationships between morphometric indicators of atrophy of the gray and white matter of the brain and the degree of disability and cognitive impairment in RRMS and SPMS.