THE CASE OF RARE CEREBRAL AUTOSOME DOMINANT ARTERIOPATHY WITH SUBCORTICAL INFARCTIONS AND LEUKOENCEPHALOPATHY

Abstract

CADASIL is a rare hereditary disease that manifests with various clinical symptoms and needs detailed examination due to its clinical non-specificity. CADASIL is one of the risk factors for cerebral ischemia and dementia. It is an inherited arterial disease caused by mutations of Notch 3 gene on chromosome 19.

The article provides information about the authors' case report discovered in a 54-year-old female patient. On a series of MR images in the white matter of both hemispheres of the brain, predominantly paraventricular and subcortical, multiple patches of the pathological MR signal of a drain character, hyperintensive MR signal in T2 mode and FLAIR mode are visualized.

Based on the existing objective changes, anamnesis and MRI results, CADASIL was diagnosed.