THE CHARACTERISTIC OF CLINICAL COURSE AND FEATURES OF HORMONAL CHANGES IN WOMEN WITH UTERINE FIBROIDS IN THE POSTMENOPAUSAL PERIOD

Abstract

The results of present study demonstrate the characteristics of clinical manifestations and features of hormonal changes in women with uterine fibroids in the postmenopausal period. 85 patients with uterine myoma in the postmenopausal period were examined. The average age of patients was 58 ± 1.0 (47-80) years. Criteria of inclusion are all patients with uterine myoma of up to 12 weeks of gestation of various localization in the postmenopausal period. In all patients, the clinical and anamnestic manifestations of uterine fibroids were studied. The state of the hypothalamicpituitary-ovarian system, the determination of the level of the CA 125 tumor. In 47 (55.3%) patients, various clinical manifestations of uterine fibroids were noted: in 37 (78.7%) patients there was pain of varying intensity, in 22 (46.8%) of patients was bloody discharge, in 17 (36.2%) dysuric phenomena, 10 (21.3%) patients had bleeding and 10 (21.3%) patients had defecation disorders. In 34 (72.3%) patients, the presence of menopausal syndrome of varying severity was noted. At the same time, the frequency of mild menopausal syndrome was 23.4% (n=11), moderate climacteric syndrome was 21.3% (n = 10), and the frequency of severe degree was 27.7% (n=13). In patients with uterine myoma in the postmenopausal period, there was a significant increase in Prl, DHEA-S, E1 and a significant decrease in the LH / FSH ratio, E2, and Ttot (p<0.05). The indicator of the CA125 tumor marker fluctuates within a fairly wide range - 1.3- 600 mIU / ml and therefore was statistically unreliable