КОРРЕЛЯЦИОННЫЕ СВЯЗИ УРОВНЯ ИНТЕРЛЕЙКИНА-6 И ИНТЕРЛЕЙКИНА-10 В КРОВИ С КРИТИЧЕСКИМ ТЕЧЕНИЕМ ИНСУЛЬТАССОЦИИРОВАННОЙ ПНЕВМОНИИ

U.G. Khanakhmedova; R.D. Mustafayev; V.A. Derbenev; M.I. Lazechko; D.Kh. Ibragimova

doi:10.34921/amj.2025.3.16

Authors

U.G. Khanakhmedova University Medical Center named after Vladimir Vinogradov of Peoples’ Friendship University of Russia named after Patrice Lumumba
R.D. Mustafayev Skobelkin Scientific and Practical Center for Laser Medicine, Federal Medical and Biological Agency of Russia (FMBA)
V.A. Derbenev Skobelkin Scientific and Practical Center for Laser Medicine, Federal Medical and Biological Agency of Russia (FMBA)
M.I. Lazechko Skobelkin Scientific and Practical Center for Laser Medicine, Federal Medical and Biological Agency of Russia (FMBA)
D.Kh. Ibragimova University Medical Center named after Vladimir Vinogradov of Peoples’ Friendship University of Russia named after Patrice Lumumba

DOI:

https://doi.org/10.34921/amj.2025.3.16

Keywords:

stroke-associated pneumonia, IL-6, IL-10, mechanic ventilation

Abstract

The article presents the results of a study conducted to determine the relationship between the level of serum cytokines and the severity of stroke-associated pneumonia (SAP). To clarify the role of cytokines in the pathogenesis of SAP, we assessed the serum levels of cytokines - IL-6 and IL-10 in 58 patients with SAP (19 in critical and 39 in non-critical condition), in the blood serum using flow cytometry.We observed a significant increase in the level of IL-6 and IL-10 in the blood serum of patients in critical condition. These cytokines were also associated with the need for mechanical ventilation and mortality, IL-6 showed AUC values above 0.7 for both variables and correlated with creatinine, sodium, and platelet levels. Conclusion: The results of the study in patients with stroke-associated pneumonia are similar and confirm previous observations regarding the involvement of IL-6 and IL-10 in the severity of pneumonia in patients with COVID-19.