PHYSICAL DEVELOPMENT OF OFFSPRING OF FEMALE RATS EXPOSED TO CALCIUM ANTAGONISTS DURING GESTATION

Abstract

The article presents the results of a study conducted to determine the effectiveness of drugs in fetuses exposed to calcium antagonists (CA) in the womb. 282 rat pups born from dams receiving CA 21 days before fertilization, throughout pregnancy and during breastfeeding were included in the study. The obtained data show that the period of eruption of incisors in rat pups born from females receiving CA during pregnancy is delayed compared to the control group. Also, in rat pups, verapamil at a dose of 5 mg/kg, and diltiazem at a dose of 5 mg/kg delayed the opening of the eyes and delayed the opening of the ear canal. Other parameters of physical development were similar to those of control group rats and no statistically significant differences were found. No significant changes were found in the nifedipine group rats during the period of physical development. It has been established that CA used during pregnancy and lactation causes a decrease in the body weight growth rate and delays in physical development in the newborn generation. The least significant changes were observed against the background of nifedipine.