ARCHITECTONICS AND STRUCTURAL ORGANIZATION OF THE HEPATIC MICROHEMOCIRCULATION BED AFTER EXPERIMENTAL APPLICATION OF CANNABIDIOL OIL

Abstract

The article presents data about the microhemocirculatory bed of the liver after the experimental use of 10% cannabidiol oil (CBD Oil 10%). The purpose of this work was the histological and immunohistochemical evaluation of the microhemocirculatory bed of the liver after 14 and 28 days of application of 10% cannabidiol oil in the experiment. The experiments were conducted on 42 male rats, aged 5-7 months, with a weight range of 180-200 g.
It was found that 10% CBD oil, which was received as a food additive by experimental animals of subgroups I and II, did not have a negative effect on the microhemocirculatory bed of the liver. After 14 and 28 days of using 10% CBD oil, the structural organization of the microhemocirculatory bed of the liver is not disturbed, the state of the vascular walls of the central veins, hepatic triads, sinusoidal capillaries does not differ from the control group, violations of the rheological properties of blood in the form of erythrostasis with diapedetic microhemorrhages, blood separation, We did not detect leukostasis, we did not diagnose pathological changes in the form of hemorrhages, inflammation and necrosis. The results of morphometry of the diameter of the central vein of both subgroups showed indicators from 87.79 μm to 90.89 μm with an average diameter of 88.73 ± 1.1 μm, which did not differ from the control group (p>0.05).
Thus, the results of histological, immunohistochemical and morphometric studies demonstrate that the use of 10% CBD oil does not pose a risk of damage to the microhemocirculatory bed of the liver.