THE FEATURES OF PHOTADITAZINE ACCUMULATION IN THE MUCOUS MEMBRANE OF BLADDER IN INTERSTITIAL CYSTITIS

Abstract

The article presents the results of a study aimed at investigating the accumulation of the photosensitizer - photoditazine in the mucous membrane of the bladder in interstitial cystitis to optimize the conduct of photodynamic therapy for this condition. The work is based on the results of examining 25 patients with interstitial cystitis.
The time of accumulation of the photoditazine in the mucous membrane of the bladder after its intravenous administration was studied using a multichannel optical fiber spectroanalyzer («LESA-01- Biospec»). For photodynamic therapy, an «ATKUS-2» laser device with an adjustable output power of up to 2 watts and a radiation wavelength of 661 ± 0.03 nm was used. The method of fluorescence spectroscopy revealed that the maximum accumulation time of the drug photoditazine in the mucous membrane of the bladder in interstitial cystitis is 120-150 minutes. After laser exposure, according to spectroscopy data, the fluorescence intensity decreases by 72.3%, which indicates a pronounced excitation of the photosensitizer and the development of an active photodynamic reaction.
Thus, it was found that the optimal time for laser irradiation in interstitial cystitis is 2-2.5 hours after the introduction of a photosensitizer. Spectroscopy data after laser exposure indicate the effectiveness of photodynamic therapy for this disease.