A STUDY OF BILIARY EXCRETION FUNCTION OF THE LIVER IN EXPERIMENTALLY INDUCED CRANIOSKELETAL INJURY

Abstract

The objective of the study was to find out the features of biliary excretion function of the liver in a setting of experimentally induced cranioskeletal injury at days 1, 3 and 7 of the post-injury period. The experimental studies were performed on 46 non linear white mature male rats. Closed traumatic brain injury and closed fracture of a thigh bones was modelled in animals of experimental group. The biliary excretion function of the liver, concentrations of total bile acids, total cholesterol, total, direct and indirect bilirubin in bile were assessed. We found that the period of early manifestations of experimentally induced cranio skeletal injury is accompanied by impaired biliary excretion function of the liver, which manifests as reduced biliary excretion rate and reduced excretion of total bile acids, total cholesterol, total and direct bilirubin. The disorders are the most pronounced at Day 7 of the post-injury period. Our results suggest that bile formation and bile excretion functions of the liver are impaired in case of cranioskeletal injury modeling, which should be considered during aggressive pharmacological therapy of multiple organ failure in polytrauma.