CLASSIFICATION AND CLINICAL PHENOMENOLOGY OF COMPENSATORY REACTIONS OF CONTACT-PROTECTIVE SYSTEMS IN PATIENTS WITH ECZEMA

Abstract

The article presents the results of a study of the frequency and nature of compensatory reactions of oxidative homeostasis and the immune protective system in patients with eczema. The functional state of the immune system in 32 patients and 15 persons of the control group was evaluated by indicators of the T- and B-phagocytic chain, and the state of oxidative homeostasis – by the indicators of lipid peroxidation of cell membranes. We used methods of variation statistics with the assessment of the significance of differences by the criterion of Student, elements of information analysis. The study showed that the altered functions of the immune system and oxidative homeostasis in eczema are characterized by at least six types of compensatory reactions, which form nine variants of clinical phenomena. The most common option is a combination of immun-and antioxidant (AO)-functional decompensation; in second place – clinical phenomena of the combination of immunoregulatory imbalance with AO-functional decompensation – 17.4±4.0% of patients. On the third – clinical phenomena of a combination of immuno- and AO-regulatory compensation rections – in 15.2±3.7% of patients with eczema. The functional decompensation of the antioxidant system detected in 58.0±4.9% of patients is significantly more likely than the immunoregulatory decompensation diagnosed in 43.5 ± 5.2% (p<0.05). A significant part of patients with eczema – 23.9±4.4% are characterized by combined immuno- and AO-functional decompensation.