МОРФО-ПАТОФИЗИОЛОГИЧЕСКИЕ АСПЕКТЫ ИЗМЕНЕНИЯ ПОЧЕК ПРИ COVID-19

С.Н. Совгиря; Б.Н. Филенко; Н.В. Ройко; И.И. Старченко; А.Ю. Пятибратов; В.Ф. Кислый

doi:10.34921/amj.2022.1.020

Авторы

С.Н. Совгиря Полтавский государственный медицинский университет
Б.Н. Филенко Полтавский государственный медицинский университет
Н.В. Ройко Полтавский государственный медицинский университет
И.И. Старченко Полтавский государственный медицинский университет
А.Ю. Пятибратов Полтавский государственный медицинский университет
В.Ф. Кислый Полтавский государственный медицинский университет

DOI:

https://doi.org/10.34921/amj.2022.1.020

Ключевые слова:

острое повреждение почек, эндотелиальная дисфункция, тромбоз, некроз эпителия канальцев почек

Аннотация

The paper presents the pathomorphological changes in the kidneys of patients, who died from severe COVID-19, and analyzed the literature to substantiate the possible pathophysiological patterns of their development. The material for the study was pieces of kidneys taken during autopsy of 16 deceased with severe COVID-19 without a history of kidney disease.

Pathological changes in COVID-19-related acute kidney injury were manifested by non-specific changes in the glomeruli, the presence of blood clots in the blood vessels, dystrophy, necrosis, and desquamation of the epithelial cells of the nephron tubules. Pathological changes in the kidney structures resulted from both the direct nephrotoxic effect of the SARS-CoV-2 virus and the indirect effect of systemic hypoxia, hypercoagulation, hyperventilation. Moreover, cross-organ damage covering the lung-kidney and heart-kidney axes was not excluded. Systemic endothelial dysfunction presumably plays one of the key roles in the development of acute kidney injury. Thus, the present study reveals the potential pathogenetic links of COVID-19-related acute kidney injury.