THE RELATIONSHIP BETWEEN UROMODULIN METABOLISM PARAMETERS AND KIDNEY FUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 1–3

Abstract

This article provides information about a study conducted to assess the association between uromodulin (Umod) metabolism parameters and kidney function in patients with chronic kidney disease (CKD) stages 1–3. This cross-sectional study included 91 patients (38.5% men, 61.5% women) diagnosed with CKD according to the KDIGO 2012 criteria. Parameters of uromodulin metabolism were evaluated (urinary uromodulin (uUmod), uUmod24, serum Umod, and their derivatives: uUmod/uCrea, uUmod/sUmod, fractional excretion of Umod), fractional secretion of Umod, etc.), and eGFR was calculated using the CKD-EPI, MDRD, and CG formulas. Statistical analysis was performed using EZR v.4.3.1; correlation analysis was used (p < 0.05). Positive correlations were identified between uUmod and its derivatives, as well as between eGFR and uUmod/eGFRCKD. Inverse correlations were found between sCrea and eGFR, and between sUrea and sUmod/BUN. FeUmod showed a positive correlation with sCrea and BUN, while FsUmod correlated positively with sUmod. These findings reflect compensatory activation of uromodulin excretion in response to declining kidney function. The most sensitive markers of early tubular alterations were uUmod/uCrea and FeUmod. Parameters of uromodulin metabolism may serve as functional biomarkers for stratifying CKD patients and detecting early tubulopathies.