THE USE OF ANTIOXIDANTS FOR GASTRODUODENAL BLEEDING OF ULCER ORIGIN WITH A HIGH RISK OF RECURRENCE

Abstract

The article presents the results of a study aimed at investigating the effect of antioxidant glutathione on the frequency of recurrent peptic ulcer bleeding in high-risk patients. The Rockall scale was utilized to determine the risk of rebleeding. A total of 55 participants were enrolled and divided into two groups: the control group (n = 20) received standard treatment according to the protocols, while the main group (n = 35) received both standard therapy and glutathione therapy. After the treatment rebleeding rate, the length of hospital stay, the need for transfusion of blood products and the mortality rate were assessed. The study's results indicate that there was a statistically significant decrease in the need for erythrocyte mass transfusion by 32.48% (p<0.001) and a 20.46% decrease (p<0.05) in the incidence of rebleeding in the main group compared to the control group. No statistically significant difference was found between other criteria.