PATHOGENETIC EFFECTIVENESS OF STEM CELLS IN ACUTE PANCREATITIS

Abstract

A clinical study was conducted on 50 patients with acute pancreatitis. The patients were divided into two groups depending on the type of treatment: the first group (n=25) received basic treatment, while the second group (n=25) received complex therapy, which included standard treatment as well as cell therapy. The study evaluated the intensity of endotoxicosis, the activity of lipid peroxidation, and the functional state of the hemostasis system. The results showed that patients with acute pancreatitis experience significant changes in the functional state of their homeostasis system in the early stages of the disease. These changes were characterized by the formation of endogenous toxemia, the activation of lipid peroxidation, and significant disruptions in the hemostasis system (including hypercoagulation and hypofibrinolysis). The type of treatment was found to be associated with these disturbances. Basic treatment was found to be ineffective in reversing these changes, which were persistent and irreversible throughout the study. However, the early use of mesenchymal stem cells in addition to drug therapy for acute pancreatitis allowed for targeted restoration of the functional state of the homeostatic system. This was supported by significant differences in the studied parameters between the main and control groups. Similar results were observed when evaluating the severity of intoxication, the activity of lipid peroxidation processes, and the hemostasis system.